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JAC Advance Access published online on June 27, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl254
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received December 2, 2005
Revised May 15, 2006
Accepted May 26, 2006

Brief report

Antibacterial activity of YC-20, a new oxazolidinone

Yingjie Cui 1 * {dagger}, Yaxian Dang 1, Yushe Yang 1 {dagger}, Shuhua Zhang 2, and Ruyun Ji 1

1 Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, Shanghai 201203, China
2 Sichuan Industrial Institute of Antibiotics, Chengdu 610051, China

* To whom correspondence should be addressed.
Yingjie Cui, E-mail: cuiyingjie{at}yahoo.com


  Abstract

Objectives and methods: YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of Gram-positive species was determined.

Results: YC-20 is a potent oxazolidinone with all isolates tested displaying MIC50 and MIC90 values of <0.5 and 2 mg/L, respectively. MICs of YC-20 for all isolates tested, with the exception of methicillin-susceptible Staphylococcus epidermidis, were similar or lower than those of linezolid.

Conclusions: This study suggests a potential new antibiotic for the treatment of infections with Gram-positive bacteria.

Keywords: antibiotics; Gram-positive; linezolid.
{dagger}These authors contributed equally to this study.
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