Skip Navigation



JAC Advance Access published online on July 1, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl224
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
58/2/256    most recent
dkl224v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Agwuh, K. N.
Right arrow Articles by MacGowan, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Agwuh, K. N.
Right arrow Articles by MacGowan, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Review

Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

Kenneth N. Agwuh 1 and Alasdair MacGowan 2 *

1 Department of Medical Microbiology, Old Medical School, Leeds General Infirmary, Great George Street, Leeds LS1 2EX, UK
2 Bristol Centre for Antimicrobial Research & Evaluation, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK

* To whom correspondence should be addressed.
Alasdair MacGowan, E-mail: alasdair.macgowan{at}nbt.nhs.uk


  Abstract

The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, represented by the glycylcycline tigecycline, is injectable only, with an improved antibacterial spectrum compared with the tetracyclines. Though incompletely understood, the pharmacodynamic properties of the tetracyclines and glycylcyclines are summarized.

Keywords: pharmacokinetics; pharmacodynamics; tetracyclines.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
V. Q. Binh, N. T. Chinh, N. X. Thanh, B. T. Cuong, N. N. Quang, B. Dai, T. Travers, and M. D. Edstein
Sex Affects the Steady-State Pharmacokinetics of Primaquine but Not Doxycycline in Healthy Subjects
Am J Trop Med Hyg, November 1, 2009; 81(5): 747 - 753.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
G. G. Zhanel, P. J. Baudry, F. Tailor, L. Cox, D. J. Hoban, and J. A. Karlowsky
Determination of the pharmacodynamic activity of clinically achievable tigecycline serum concentrations against clinical isolates of Escherichia coli with extended-spectrum {beta}-lactamases, AmpC {beta}-lactamases and reduced susceptibility to carbapenems using an in vitro model
J. Antimicrob. Chemother., October 1, 2009; 64(4): 824 - 828.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
P. Starzengruber, K. Thriemer, R. Haque, W. A. Khan, H. P. Fuehrer, A. Siedl, V. Hofecker, B. Ley, W. H. Wernsdorfer, and H. Noedl
Antimalarial Activity of Tigecycline, a Novel Glycylcycline Antibiotic
Antimicrob. Agents Chemother., September 1, 2009; 53(9): 4040 - 4042.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
B. A. Cunha
Pharmacokinetic Considerations regarding Tigecycline for Multidrug-Resistant (MDR) Klebsiella pneumoniae or MDR Acinetobacter baumannii Urosepsis
J. Clin. Microbiol., May 1, 2009; 47(5): 1613 - 1613.
[Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
C. Ishikawa, T. Tsuda, H. Konishi, N. Nakagawa, and K. Yamanishi
Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes
Antimicrob. Agents Chemother., May 1, 2009; 53(5): 1760 - 1765.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. L. Crandon, M. A. Banevicius, and D. P. Nicolau
Pharmacodynamics of Tigecycline against Phenotypically Diverse Staphylococcus aureus Isolates in a Murine Thigh Model
Antimicrob. Agents Chemother., March 1, 2009; 53(3): 1165 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
K. E. Bowker, A. R. Noel, and A. P. MacGowan
Pharmacodynamics of Minocycline against Staphylococcus aureus in an In Vitro Pharmacokinetic Model
Antimicrob. Agents Chemother., December 1, 2008; 52(12): 4370 - 4373.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
M. Sousa, A. Pozniak, and M. Boffito
Pharmacokinetics and pharmacodynamics of drug interactions involving rifampicin, rifabutin and antimalarial drugs
J. Antimicrob. Chemother., November 1, 2008; 62(5): 872 - 878.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
A. P. MacGowan
Tigecycline pharmacokinetic/pharmacodynamic update
J. Antimicrob. Chemother., September 1, 2008; 62(suppl_1): i11 - i16.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
K. T. Batty, A. S. F. Law, V. Stirling, and B. R. Moore
Pharmacodynamics of Doxycycline in a Murine Malaria Model
Antimicrob. Agents Chemother., December 1, 2007; 51(12): 4477 - 4479.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Kielian, N. Esen, S. Liu, N. K. Phulwani, M. M. Syed, N. Phillips, K. Nishina, A. L. Cheung, J. D. Schwartzman, and J. J. Ruhe
Minocycline Modulates Neuroinflammation Independently of Its Antimicrobial Activity in Staphylococcus aureus-Induced Brain Abscess
Am. J. Pathol., October 1, 2007; 171(4): 1199 - 1214.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
C. M Slover, K. A Rodvold, and L. H Danziger
Tigecycline: A Novel Broad-Spectrum Antimicrobial
Ann. Pharmacother., June 1, 2007; 41(6): 965 - 972.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
H. S. Sader, M. J. Ferraro, L. B. Reller, P. C. Schreckenberger, J. M. Swenson, and R. N. Jones
Reevaluation of Clinical and Laboratory Standards Institute Disk Diffusion Breakpoints for Tetracyclines for Testing Enterobacteriaceae
J. Clin. Microbiol., May 1, 2007; 45(5): 1640 - 1643.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.