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JAC Advance Access published online on May 15, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl190
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received January 17, 2006
Revised April 13, 2006
Accepted April 18, 2006

Original article

Endothelial function in HIV-infected patients with low or mild cardiovascular risk

Juan José Ríos Blanco 1 *, Inés Suárez García 1, Jorge Gómez Cerezo 1, José María Peña Sánchez de Rivera 1, Pilar Moreno Anaya 2, Pilar García Raya 2, Juan González García 1, José Ramón Arribas López 1, Francisco Javier Barbado Hernández 1, and Juan José Vázquez Rodríguez 1

1 Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
2 Department of Radiology, Hospital Universitario La Paz, Madrid, Spain

* To whom correspondence should be addressed.
Juan José Ríos Blanco, E-mail: juanjo.rios{at}gmail.com


  Abstract

Background: Highly active antiretroviral therapy for HIV-infected patients is associated with metabolic side effects, which could cause an increased cardiovascular risk in these patients. Non-invasive study of endothelial function by brachial artery ultrasound can detect subclinical atherosclerosis. Several studies have assessed endothelial function in HIV-infected patients with associated cardiovascular risk factors.

Objectives: The aim of this study is to determine endothelial function in HIV-infected patients under antiretroviral therapy with low or mild coronary risk and lipid levels within the normal range.

Methods: Transversal study including 28 HIV-infected adults (15 receiving antiretroviral therapy and 13 naive) with low or mild cardiovascular risk and 12 healthy controls. Subjects with diabetes mellitus, hypertension, cardiovascular disease, obesity, high cholesterol or high triglyceride levels were excluded. Endothelial function was determined with flow-mediated dilation (FMD) of the brachial artery by ultrasound study.

Results: Treated HIV-infected patients had significantly lower FMD (5.93 ± 3.56) than healthy controls (10.64 ± 3.08, P = 0.008). Naive patients had an intermediate FMD, but this was not statistically significant.

Conclusions: HIV-infected patients receiving antiretroviral therapy who have low or mild cardiovascular risk and lipid levels within the normal range have endothelial dysfunction compared with healthy controls.

Keywords: atherosclerosis; risk factors; antiretroviral therapy.
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