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JAC Advance Access published online on May 23, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl170
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

Does interferon improve portal hypertension?

Diego Rincón 1, Cristina Ripoll 1, María Vega Catalina 1, Magdalena Salcedo 1, and Rafael Bañares 1 *

1 Hospital General Universitario Gregorio Marañón, Dr Esquerdo 46, 28007, Madrid, Spain

* To whom correspondence should be addressed.
Rafael Bañares, E-mail: rbanares{at}telefonica.net


  Abstract

Chronic hepatitis C is the leading cause of advanced liver disease in the Western world. Most patients with liver cirrhosis develop portal hypertension (PHT) (i.e. an abnormal gradient between portal and inferior vena cava pressures), responsible for the most frequent and severe complications of liver disease and, as a consequence, the main cause of death and liver transplantation in those patients. The existence of a potential beneficial effect of antiviral therapy (AVT) on liver inflammation and fibrosis, partially independent of the degree of virological response, has been recently reported. However, the possible influence of these histological changes on PHT has not been evaluated. In this article, we summarize the available findings regarding the effect of AVT on PHT in patients with advanced chronic hepatitis C, as well as its possible implications for clinical practice and future avenues of investigation.

Keywords: hepatitis C; liver cirrhosis; hepatic venous pressure gradient; antiviral therapy.
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