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JAC Advance Access published online on April 14, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl132
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received July 30, 2005
Revised March 15, 2006
Accepted March 20, 2006

Brief report

In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb

Yaya Rukayadi 1, Dongeun Yong 2, and Jae-Kwan Hwang 3 *

1 Department of Biotechnology & Bioproducts Research Center (BRC), Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, Korea; Research Center for Bioresources and Biotechnology, Bogor Agricultural University, Bogor 16880, Indonesia
2 Department of Laboratory Medicine & Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Yonsei University, Seoul 120-749, Korea
3 Department of Biotechnology & Bioproducts Research Center (BRC), Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, Korea

* To whom correspondence should be addressed.
Jae-Kwan Hwang, E-mail: jkhwang{at}yonsei.ac.kr


  Abstract

Objectives: Xanthorrhizol, isolated from the methanol extract of Curcuma xanthorrhiza Roxb., was investigated for its anticandidal activity using six Candida species.

Methods: The in vitro susceptibility tests for xanthorrhizol were carried out in terms of MIC and minimal fungicidal concentration (MFC) using the NCCLS M27-A2 broth microdilution method. Time-kill curves were determined to assess the correlation between MIC and fungicidal activity of xanthorrhizol at concentrations ranging from 0 MIC to 4x MIC.

Results: All Candida species showed susceptibility to xanthorrhizol in the MIC range 1.0-15.0 mg/L for Candida albicans, 1.0-10 mg/L for Candida glabrata, 2.0-8.0 mg/L for Candida guilliermondii, 2.5-7.5 mg/L for Candida krusei, 2.5-25 mg/L for Candida parapsilosis and 2.0-8.0 mg/L for Candida tropicalis. Time-kill curves demonstrated that xanthorrhizol was able to kill the Candida strains with MFCs of 20 mg/mL, 15 mg/mL, 12.5 mg/mL, 10 mg/L, 30 mg/mL and 10 mg/L for C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis and C. tropicalis, respectively.

Conclusions: The potent anticandidal activity of xanthorrhizol may support the use of C. xanthorriza for the treatment of candidiasis.

Keywords: C. xanthorriza; MIC; MFC; antifungals.
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