Skip Navigation



JAC Advance Access published online on April 4, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl123
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
57/6/1030    most recent
dkl123v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Osborn, M. K.
Right arrow Articles by Lok, A. S. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Osborn, M. K.
Right arrow Articles by Lok, A. S. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

Antiviral options for the treatment of chronic hepatitis B

Melissa K. Osborn 1 and Anna S. F. Lok 2 *

1 Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA; Present address. University of Michigan Medical Center, Division of Gastroenterology, 1500 E. Medical Center Drive, 3912 Taubman Center, Ann Arbor, MI 48109-0362, USA
2 Division of Gastroenterology, University of Michigan Medical Center, 1500 E. Medical Center Drive, 3912 Taubman Center, Ann Arbor, MI 48109-0362, USA

* To whom correspondence should be addressed.
Anna S. F. Lok, E-mail: aslok{at}med.umich.edu


  Abstract

Hepatitis B virus (HBV) is an important cause of end-stage liver disease and hepatocellular carcinoma. Effective treatment can delay or prevent these outcomes. The decision to treat is based on the activity of liver disease and HBV replication status, and the likelihood of a long-term benefit. Approved therapies include standard and pegylated interferon-alfa and nucleoside analogues: lamivudine, adefovir and entecavir. Current therapies do not eradicate HBV so long-term treatment is usually required. Development of drug resistance is a major concern with long-term treatment. Even with successful therapy, patients remain at risk for reactivation of viral replication and require lifelong monitoring.

Keywords: interferon; lamivudine; adefovir; entecavir; natural history.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
P.-F. Lin, B. Nowicka-Sans, B. Terry, S. Zhang, C. Wang, L. Fan, I. Dicker, V. Gali, H. Higley, N. Parkin, et al.
Entecavir Exhibits Inhibitory Activity against Human Immunodeficiency Virus under Conditions of Reduced Viral Challenge
Antimicrob. Agents Chemother., May 1, 2008; 52(5): 1759 - 1767.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.