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JAC Advance Access published online on March 23, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl073
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

Human papillomavirus viral load: a possible marker for cervical disease in HIV-infected women

Flavia B. Lillo 1 * and Caterina Uberti-Foppa 2

1 Laboratory of Virology, AIDS Center San Luigi, Via Stamira D'Ancona 20, San Raffaele Scientific Institute, 20127 Milan, Italy
2 Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy

* To whom correspondence should be addressed.
Flavia B. Lillo, E-mail: lillo.flavia{at}hsr.it


  Abstract

Laboratory markers of human papillomavirus infection have been recognized as relevant tools in programmes designed to reduce the burden of cervical cancer. The ongoing experience with these laboratory markers serves to confirm not only their negative predictive value (close to 100%) but also their positive association with developing or developed lesions. This aspect is particularly relevant in HIV-infected subjects who show an increased prevalence, incidence and severity of infections and lesions even in the era of efficacious control of their immunosuppression. Among the possible virus-related parameters proposed as relevant markers (viral persistence, load, expression, genomic integration capacity) we here analyse the informative value of human papillomavirus viral load measurement as a possible risk marker in this particular clinical setting.

Keywords: viral load; cervical cancer; prevention.
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