Skip Navigation



JAC Advance Access published online on February 3, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl007
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
57/4/720    most recent
dkl007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Gerber, P.
Right arrow Articles by Cottagnoud, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gerber, P.
Right arrow Articles by Cottagnoud, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original article

Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis

Peter Gerber 1, Armin Stucki 2, Fernando Acosta 3, Marianne Cottagnoud 3, and Philippe Cottagnoud 2 *

1 Clinic of Pneumology, Inselspital, Bern, Switzerland
2 Department of Internal Medicine, Inselspital, Bern, Switzerland
3 Clinic of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland

* To whom correspondence should be addressed.
Philippe Cottagnoud, E-mail: pcottagn{at}insel.ch


  Abstract

Objectives: To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meninges

Results: Over a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (-4.54 ± 1.12 log10/mL for daptomycin versus -3.43 ± 1.17 log10/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was ~5% and ~2% into non-inflamed meninges.

Conclusions: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.

Keywords: bacterial meningitis; treatment; S. aureus; cyclic lipopeptide.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
R. Naesens, M. Ronsyn, P. Druwe, O. Denis, M. Ieven, and A. Jeurissen
Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus
J. Med. Microbiol., September 1, 2009; 58(9): 1247 - 1251.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
U. Egermann, Z. Stanga, A. Ramin, F. Acosta, A. Stucki, P. Gerber, M. Cottagnoud, and P. Cottagnoud
Combination of Daptomycin plus Ceftriaxone Is More Active than Vancomycin plus Ceftriaxone in Experimental Meningitis after Addition of Dexamethasone
Antimicrob. Agents Chemother., July 1, 2009; 53(7): 3030 - 3033.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
F. K. Gould, R. Brindle, P. R. Chadwick, A. P. Fraise, S. Hill, D. Nathwani, G. L. Ridgway, M. J. Spry, R. E. Warren, and on behalf of the MRSA Working Party of the British
Guidelines (2008) for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the United Kingdom
J. Antimicrob. Chemother., May 1, 2009; 63(5): 849 - 861.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
R. E. Warren
Daptomycin in endocarditis and bacteraemia: a British perspective
J. Antimicrob. Chemother., November 1, 2008; 62(suppl_3): iii25 - iii33.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
L. Spanjaard and C. M. J. E. Vandenbroucke-Grauls
Activity of Daptomycin against Listeria monocytogenes Isolates from Cerebrospinal Fluid
Antimicrob. Agents Chemother., May 1, 2008; 52(5): 1850 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. Stucki, M. Cottagnoud, V. Winkelmann, T. Schaffner, and P. Cottagnoud
Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [3H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall
Antimicrob. Agents Chemother., June 1, 2007; 51(6): 2249 - 2252.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.