JAC Advance Access published online on January 31, 2006
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki483
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1 Service d'Infectiologie, Hôpital l'Archet 1, Centre Hospitalier Universitaire de Nice, Nice, France
* To whom correspondence should be addressed. Objectives: Several studies have reported that infectious diseases (ID) consultations improve the quality of antibiotic prescription, providing adherence is adequate. The aim of this study is to determine the factors associated with adherence to such therapeutic advice. Patients and methods: We conducted a prospective study in two intensive care units (ICUs) over a 6 month period. Systematic bedside diagnostic and therapeutic ID advice was delivered for all patients receiving antibiotic therapy. Results: A total of 381 consultations for 195 patients were recorded, 244 (64%) in ward A and 137 (36%) in ward B. The median SAPS score was 45 and the mortality rate was 23%. Infections accounted for 220 (58%) admissions. A diagnostic discrepancy between ID and intensive care specialists was noted in 125 (33%) cases. The ID specialist advised continuation of the same antibiotic therapy in 138 (36%) cases, a change in 154 (41%) and withdrawal in 89 (23%). Adherence to ID therapeutic advice was recorded for 326 (86%) cases. Multivariate analysis identified two factors independently associated with adherence: ward B [odds ratio (OR), 4.9; 95% confidence interval (CI), 2.0-12.1] and proposition to pursue the same therapy (OR, 4.8; 95% CI, 1.6-14.5). Conclusions: Patients' characteristics and antibiotic therapy modalities do not influence adherence to ID consultation. In contrast, the ward and its characteristics play a major role in adherence to ID advice.
Received August 3, 2005
Revised December 5, 2005
Accepted December 12, 2005
Antimicrobial practice
Factors associated with adherence to infectious diseases advice in two intensive care units
Céline Pulcini 1 *,
Christian Pradier 2,
Corinne Samat-Long 3,
Hervé Hyvernat 4,
Gilles Bernardin 4,
Carole Ichai 3,
Pierre Dellamonica 1,
and
Pierre-Marie Roger 1
2 Département de Santé Publique, Hôpital l'Archet 1, Centre Hospitalier Universitaire de Nice, Nice, France
3 Réanimation polyvalente, Hôpital St Roch, Centre Hospitalier Universitaire de Nice, Nice, France
4 Réanimation médicale, Hôpital l'Archet 1, Centre Hospitalier Universitaire de Nice, Nice, France
Céline Pulcini, E-mail: pulcini.c{at}chu-nice.fr
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