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JAC Advance Access published online on November 30, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki430
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received January 14, 2005
Revised July 1, 2005
Accepted October 24, 2005

Original article

Pathological changes in the brains of rabbits experimentally infected with Angiostrongylus cantonensis after albendazole treatment: histopathological and magnetic resonance imaging studies

Lian-Chen Wang 1, Shih-Ming Jung 2, Chien-Chuan Chen 3, Ho-Fai Wong 3, Dinah-Pingni Wan 4, and Yung-Liang Wan 3 *

1 Department of Parasitology, College of Medicine, Chang-Gung University, Kueisan, Taoyuan 333, Taiwan
2 Department of Pathology, Chang-Gung Memorial Hospital, Chang-Gung Children Hospital at Linkou and Chang-Gung University, Kueisan, Taoyuan 333, Taiwan
3 Department of Diagnostic Radiology, Chang-Gung Memorial Hospital at Linkou, College of Medicine, Chang-Gung University, Kueisan, Taoyuan 333, Taiwan
4 College of Arts and Sciences, Case Western Reserve University, Cleveland, OH, USA

* To whom correspondence should be addressed.
Yung-Liang Wan, E-mail: ylw0518{at}adm.cgmh.org.tw


  Abstract

Objectives: To determine the effects of albendazole on rabbits infected with larvae of Angiostrongylus cantonensis by histopathological and magnetic resonance imaging (MRI) techniques.

Methods: Male rabbits were infected with 400 A. cantonensis larvae and treated with albendazole (5 mg/kg/day) for 2-14 days on day 5, 10, 15 or 20 post-infection.

Results: Although there were pathological changes in the brains, MRI revealed unremarkable findings in the untreated group. However, the treated rabbits exhibited eosinophilic meningitis, choroid plexus inflammation, meningeal congestion, encephalitis, perivascular cuffing and meningitis, and were also found to have abnormal signal intensities on brain MR images in the 20 day post-infection treated group.

Conclusions: Pathological changes in the brains of the treated rabbits are more severe than those without albendazole treatment, suggesting that the drug may not be very suitable for the treatment of cerebral angiostrongyliasis.

Keywords: A. cantonensis; MRI; pathology; histopathology; angiostrongyliasis; anthelmintics.
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