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JAC Advance Access published online on September 9, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki295
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Received May 4, 2005
Revised July 12, 2005
Accepted July 26, 2005

Original article

In vivo activity of mutacin B-Ny266

Marilaine Mota-Meira 1, Helene Morency 2, and Marc C. Lavoie 3*

1 Department of Biological and Chemical Sciences, Faculty of Pure and Applied Sciences, The University of the West Indies, Cave Hill Campus, PO Box 64, Bridgetown, Barbados
2 Département de Biochimie et Microbiologie, Faculté des Sciences et de Génie, Université Laval, Québec, Canada
3 Department of Biological and Chemical Sciences, Faculty of Pure and Applied Sciences, The University of the West Indies, Cave Hill Campus, PO Box 64, Bridgetown, Barbados; Département de Biochimie et Microbiologie, Faculté des Sciences et de Génie, Université Laval, Québec, Canada

* To whom correspondence should be addressed.
Marc C. Lavoie, E-mail: mlavoie{at}uwichill.edu.bb


  Abstract

Objectives: The objective of this study was to assess the in vivo activity of mutacin B-Ny266 (a bacteriocin produced by Streptococcus mutans) in order to eventually use it as an antibiotic.

Methods: Intraperitoneal infection was induced with a methicillin-susceptible Staphylococcus aureus strain in mice. Some of the mice were simultaneously injected intraperitoneally with mutacin B-Ny266, some with the vehicle only and some with vancomycin.

Results: While there was 70 and 100% mortality in the control groups of mice, no mortality was observed in the mice injected with vancomycin or mutacin B-Ny266.

Conclusions: The results presented here show, for the first time, the in vivo efficacy of a mutacin (B-Ny266) against an experimental intraperitoneal infection by S. aureus in a mouse model.

Keywords: antimicrobial peptides; lantibiotics; Streptococcus mutans; MIC; MBC.
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