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JAC Advance Access published online on June 24, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki228
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org
Received March 16, 2005
Revised May 27, 2005
Accepted June 2, 2005

Brief report

Colicins prevent colonization of urinary catheters

Barbara W. Trautner 1*, Richard A. Hull 2, and Rabih O. Darouiche 3

1 Department of Medicine, Infectious Diseases Section, Baylor College of Medicine, Houston, TX, USA; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA
2 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA; Center for Prostheses Infection, Baylor College of Medicine, Houston, TX, USA
3 Department of Medicine, Infectious Diseases Section, Baylor College of Medicine, Houston, TX, USA; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA; Center for Prostheses Infection, Baylor College of Medicine, Houston, TX, USA; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA

* To whom correspondence should be addressed.
Barbara W. Trautner, E-mail: trautner{at}bcm.tmc.edu


  Abstract

Objectives: Natural microbial defence systems, such as bacteriocins, may be a novel means to prevent catheter-associated urinary tract infection. We investigated in vitro whether a colicin-expressing strain of Escherichia coli could prevent urinary catheter colonization by a colicin-susceptible, uropathgenic strain of E. coli.

Methods: Segments of urinary catheter were inoculated with colicin-producing E. coli K-12 and then exposed to either colicin-susceptible E. coli (a uropathogenic clinical isolate) or colicin-resistant E. coli (derived from the susceptible clinical isolate). Catheters were then incubated overnight, rinsed and sonicated.

Results: The presence of colicin-producing E. coli K-12 on the catheter surface completely prevented catheter colonization by colicin-susceptible E. coli but not by resistant E. coli. The colicin-susceptible strain but not the colicin-resistant strain also disappeared from broth cultures in the presence of colicin-producing E. coli K-12.

Conclusions: The observed inhibition of catheter colonization by the uropathogenic clinical isolate of E. coli can be attributed to the presence of a colicin-producing strain of E. coli on the catheter surface. Bacteriocin production by a non-pathogenic organism may have clinical applicability as a means to prevent catheter-associated urinary tract infection.

Keywords: bacteriocins; UTIs; uropathogens.
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