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JAC Advance Access published online on May 24, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki164
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org
Received October 27, 2004
Revised March 18, 2005
Accepted April 20, 2005

Original article

Ciprofloxacin resistance in non-typhoidal Salmonella serotypes in Scotland, 1993-2003

A. Murray 1, J. E. Coia 1, H. Mather 1, and D. J. Brown 1*

1 Scottish Salmonella Reference Laboratory, Stobhill Hospital, 133 Balornock Road, Glasgow G21 3UW, UK

* To whom correspondence should be addressed.
D. J. Brown, E-mail: Derek.Brown{at}northglasgow.scot.nhs.uk


  Abstract

Objectives: To determine the levels of resistance to ciprofloxacin among non-typhoidal salmonellae in Scotland.

Methods: Etest strips were used to determine the ciprofloxacin MICs for nalidixic acid-resistant salmonellae isolated from humans during 1993-2003.

Results: The percentage of nalidixic acid-resistant salmonellae isolated from human infection in Scotland has increased from 1.4% in 1993, to 8.8% in 1998 and 21.3% in 2003. Of 493 strains of nalidixic acid-resistant Salmonella tested, a single isolate of Salmonella Typhimurium RDNC was resistant to ciprofloxacin at the NCCLS breakpoint of 4 mg/L. Eleven isolates were resistant at the Scottish Salmonella Reference Laboratory breakpoint of 0.5 mg/L, while 466 isolates (94.5%) had reduced susceptibility with MICs of ≥0.125 mg/L < 0.5 mg/L.

Conclusions: These results show that very few non-typhoidal isolates of Salmonella in Scotland that are resistant to nalidixic acid are also resistant to ciprofloxacin at the NCCLS recommended breakpoint of 4 mg/L. The majority of isolates examined, however, do show reduced susceptibility at 0.125 mg/L. This confirms the necessity for continuing antimicrobial surveillance of resistance to this important antibiotic.

Keywords: resistance surveillance; fluoroquinolones; Etest.
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