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JAC Advance Access first published online on April 11, 2005
This version published online on May 13, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki111
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org
Received October 27, 2004
Revised March 1, 2005
Accepted March 4, 2005

Original article

In vitro activity of linezolid, clarithromycin and moxifloxacin against clinical isolates of Mycobacterium kansasii

Remedios Guna 1, Carlos Muñoz 2, Victoria Domínguez 2, Ángeles García-García 3, Jorge Gálvez 3, Jesús-Vicente de Julián-Ortiz 3, and Rafael Borrás 2*

1 Departamento de Microbiología, Facultad de Medicina y Hospital Clínico Universitario, Universidad de Valencia, Av. Blasco Ibáñez 17, 46010 Valencia, Spain; Unidad de Investigación de Diseño de Fármacos y Conectividad Molecular, Departamento de Química Física, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
2 Departamento de Microbiología, Facultad de Medicina y Hospital Clínico Universitario, Universidad de Valencia, Av. Blasco Ibáñez 17, 46010 Valencia, Spain
3 Unidad de Investigación de Diseño de Fármacos y Conectividad Molecular, Departamento de Química Física, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain

* To whom correspondence should be addressed.
Rafael Borrás, E-mail: Rafael.Borras{at}uv.es


  Abstract

Objectives: To compare the activity of linezolid with a range of drugs used in the treatment of Mycobacterium kansasii infections.

Methods: The in vitro activity of clarithromycin, ethambutol, isoniazid, linezolid, moxifloxacin and rifampicin against 104 M. kansasii clinical isolates was studied by a broth-microdilution method.

Results: The percentages of resistant isolates against isoniazid, rifampicin and ethambutol were 2.9%, 1.9% and 2.9%, respectively. All isolates were susceptible to clarithromycin and moxifloxacin both with MIC90 values of 0.125 mg/L. Linezolid was active against all isolates with MIC50 and MIC90 values of 0.5 and 1 mg/L, respectively, both below the susceptibility breakpoint established for mycobacteria.

Conclusion: Linezolid, clarithromycin or moxifloxacin, could be used as alternative drugs for treatment of infections due to rifampicin-resistant isolates as well as short-course or intermittent therapy of M. kansasii lung disease.

Keywords: non-tuberculous mycobacteria; antimycobacterial agents; broth microdilution method.
The originally published version of this article was incorrect. The Methods section was missing from the abstract. The publisher apologizes for this omission.
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