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JAC Advance Access published online on April 11, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki107
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org
Received June 22, 2004
Revised December 15, 2005
Accepted February 25, 2005

Brief report

Evaluation of the in vitro activity of NVP-LMB415 against clinical anaerobic isolates with emphasis on the Bacteroides fragilis group

David R. Snydman 1*, Nilda V. Jacobus 2, and Laura A. McDermott 2

1 Tufts-New England Medical Center, Boston, MA 02111, USA; Tufts University School of Medicine, Boston, MA 02111, USA
2 Tufts-New England Medical Center, Boston, MA 02111, USA

* To whom correspondence should be addressed.
David R. Snydman, E-mail: dsnydman{at}tufts-nemc.org


  Abstract

Objectives: To compare the in vitro activity of NVP-LMB415 (formerly referred to as NVP-PDF 713) with that of other agents with anti-anaerobe activity against clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group.

Methods: The MICs for 405 B. fragilis group and 102 Gram-positive anaerobic isolates were determined using NCCLS-recommended procedures. The activity of NVP-LMB415 was compared with that of cefoxitin, clindamycin, imipenem, garenoxacin, linezolid, moxifloxacin and tigecycline. Vancomycin was included in the evaluation of the Gram-positive organisms.

Results: NVP-LMB415 showed excellent in vitro activity against all the species of the B. fragilis group isolates (MIC range ≤ 0.03-0.5 mg/L and MIC90 0.5 mg/L). NVP-LMB415 was active against B. fragilis group strains resistant to {beta}-lactams, quinolones or clindamycin, and the MICs were much lower than those of newer agents such as linezolid, tigecycline and garenoxacin. The MICs of NVP-LMB415 ( ≥ 4 mg/L) for Clostridium species were higher than the MICs for other anaerobes.

Conclusions: Given the frequency of isolation of anaerobic bacteria and their increasing resistance to all classes of antibiotics, NVP-LMB415 is an ideal agent for potential use against mixed infections caused by resistant anaerobic pathogens such as of B. fragilis and Gram-positive aerobic strains such as methicillin-resistant staphylococci, streptococci and enterococci.

Keywords: novel peptide deformylase inhibitor; peptide deformylase inhibitor (PDF); bacterial metalloproteases; anaerobic pathogens.
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