Skip Navigation



JAC Advance Access published online on April 6, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki097
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
55/5/788    most recent
dki097v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bertin, G.
Right arrow Articles by Deloron, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertin, G.
Right arrow Articles by Deloron, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org
Received July 7, 2004
Revised November 26, 2004
Accepted February 15, 2005

Brief report

High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal

Gwladys Bertin 1, Nicaise Tuikue Ndam 1, Sayeh Jafari-Guemouri 1, Nadine Fievet 2, Emily Renart 1, Sokhna Sow 3, Jean-Yves Le Hesran 2, and Philippe Deloron 1*

1 Institut de Recherche pour le Développement (IRD), UR010, Mother and Child Health in the Tropics, Faculté de Pharmacie, 75006 Paris, France
2 IRD UR010, BP1386 CP 18524 Dakar, Senegal
3 Hôpital de Thiadiaye, Thiadiaye, Senegal

* To whom correspondence should be addressed.
Philippe Deloron, E-mail: Philippe.Deloron{at}ird.fr


  Abstract

Objectives: The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite Plasmodium falciparum chloroquine resistance. Chloroquine resistance is associated with the pfcrt gene K76T mutation. The aim of this study was to compare the prevalence rate of pfcrt T76 mutation in P. falciparum isolates from infected pregnant and non-pregnant individuals from Senegal.

Methods: The study was conducted in the rural maternity hospital of Thiadiaye, Senegal, where malaria is seasonal. Sixty-nine P. falciparum isolates from infected women were collected at delivery. These women were part of a cohort study; they were followed from their first antenatal visit and advised to take chloroquine prophylaxis. For each woman, the earliest P. falciparum-infected blood sample was also used. A control group of 49 non-pregnant individuals with asymptomatic P. falciparum infection was enrolled.

Results: During pregnancy, prevalence of T76 mutant parasites was higher than in the 49 non-pregnant controls (P <0.001). Among pregnant women, this rate was highest at delivery (P=0.06), and tended to be higher in women who had taken chloroquine prophylaxis, as assessed in urine samples (P=0.08).

Conclusions: Chloroquine prophylaxis is responsible for increased drug consumption and increased drug pressure that may lead to the selection of drug-resistant parasites. This is the first report showing that P. falciparum-infected pregnant women harbour pfcrt T76 mutant parasites more often than non-pregnant individuals, and that the prevalence of this mutation is higher at term than earlier during pregnancy.

Keywords: malaria; pregnancy; drug resistance.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
M. Niang, L. Marrama, M. T. Ekala, G. Alioune, A. Tall, J. L. Ndiaye, D. Sarr, J. M. Dangou, J. Y. Lehesran, C. Bouchier, et al.
Accumulation of CVIET Pfcrt allele of Plasmodium falciparum in placenta of pregnant women living in an urban area of Dakar, Senegal
J. Antimicrob. Chemother., November 1, 2008; 62(5): 921 - 928.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
D. SARR, L. MARRAMA, A. GAYE, J. M. DANGOU, M. NIANG, O. MERCEREAU-PUIJALON, J. Y. LEHESRAN, and R. JAMBOU
High prevalence of placental malaria and low birth weight in sahelian periurban area.
Am J Trop Med Hyg, July 1, 2006; 75(1): 171 - 177.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.