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JAC Advance Access published online on March 16, 2005

Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki079
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Leading article

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update

Johan W. Mouton 1*, Michael N. Dudley 2, Otto Cars 3, Hartmut Derendorf 4, and George L. Drusano 5

1 Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 sz Nijmegen, The Netherlands
2 Diversa Corp., San Diego, CA, USA
3 Department of Infectious Diseases, Uppsala University Hospital, Uppsala, Sweden
4 Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
5 Ordway Research Institute, Albany, New York, NY, USA

* To whom correspondence should be addressed.
Johan W. Mouton, E-mail: Mouton{at}cwz.nl


   Abstract

Interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased over recent years. Since the appearance 2 years ago of our first article describing terminology in PK/PD, the field has continued to expand rapidly, urgently requiring an update. This paper describes in a uniform manner the use of PK/PD expressions for antimicrobial agents, and their units.

Keywords: AUC/MIC; T>MIC; probability of target attainment; cumulative fraction of response; protein binding.
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