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JAC Advance Access published online on February 22, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki024
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JAC © The British Society for Antimicrobial Chemotherapy 2005; all rights reserved
Received March 19, 2004
Revised November 14, 2004
Accepted December 15, 2004

Brief report

Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice

Mochiyoshi Ninomiya 1, Hiroshige Mikamo 2*, Kaori Tanaka 3, Kunitomo Watanabe 3, and Teruhiko Tamaya 1

1 Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
2 Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan; Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan
3 Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan

* To whom correspondence should be addressed.
Hiroshige Mikamo, E-mail: mikamo{at}cc.gifu-u.ac.jp


  Abstract

Objectives: We investigated the effects of fluconazole and micafungin for the therapy of deep-seated candidiasis in a cyclophosphamide-induced immunosuppressed mouse model.

Methods: We used the experimental model of intraperitoneal fungal abscess caused by Candida albicans, as described previously.

Results and conclusions: Micafungin efficacy was equal to that of fluconazole in one-tenth dosage even in peritonitis. We also assessed the short-term (24 h) and long-term (8 days) therapeutic effects after the end of therapy. Although the therapeutic effect of fluconazole was similar to that of micafungin at 24 h after the end of therapy, the effect of micafungin was superior to that of fluconazole at 8 days after the end of therapy.

Keywords: micafungin; fluconazole; experimental infection; Candida albicans.
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