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JAC Advance Access published online on February 10, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki022
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JAC © The British Society for Antimicrobial Chemotherapy 2005; all rights reserved
Received March 3, 2004
Revised November 21, 2004
Accepted December 15, 2004

Original article

Antifungal activity of posaconazole compared with fluconazole and amphotericin B against yeasts from oropharyngeal candidiasis and other infections

Alfonso-Javier Carrillo-Munoz 1*, Guillermo Quindós 2, Maite Ruesga 2, Rocío Alonso 2, Oscar del Valle 3, Juan Manuel Hernández-Molina 4, Paul McNicholas 5, David Loebenberg 5, and Patricia Santos 6

1 Departamento de Microbiología, ACIA, PO Box 10178, E-08080 Barcelona, Spain
2 Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina, Universidad del País Vasco, Bilbao, Spain
3 Servicio de Microbiología, Hospital Vall d'Hebrón, Barcelona, Spain
4 Servicio de Microbiología, Hospital La Inmaculada, Huércal-Overa, Almería, Spain
5 Schering-Plough Research Institute, Kenilworth, NJ, USA
6 Hospital de Pediatría Pablo Garrahan, Buenos Aires, Argentina

* To whom correspondence should be addressed.
Alfonso-Javier Carrillo-Munoz, E-mail: acarrillo{at}ya.com


  Abstract

Objectives: The in vitro antifungal activity of posaconazole was compared with that of fluconazole and amphotericin B.

Materials and methods: A microdilution method (M27-A2) was used with 331 clinical yeast isolates.

Results: The geometric mean MICs of posaconazole, fluconazole and amphotericin B were 0.16, 0.91 and 0.15 mg/L, respectively. Posaconazole was markedly more active than fluconazole and was active against 9/11 fluconazole-resistant Candida albicans, and five Candida glabrata had an MIC of posaconazole of 16 mg/L.

Conclusions: These data indicate that posaconazole is a potentially effective antifungal agent for the treatment of mycoses caused by yeasts.

Keywords: susceptibility; opportunistic; Candida.
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