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JAC Advance Access published online on February 4, 2005
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dki020
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JAC © The British Society for Antimicrobial Chemotherapy 2005; all rights reserved
Received July 13, 2004
Revised November 30, 2004
Accepted December 15, 2004

Original article

Susceptibility profile of 29 clinical isolates of Rhodotorula spp. and literature review

Alicia Gomez-Lopez 1, Emilia Mellado 1, Juan L. Rodriguez-Tudela 1, and Manuel Cuenca-Estrella 1*

1 Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda (Madrid), Spain

* To whom correspondence should be addressed.
Manuel Cuenca-Estrella, E-mail: mcuenca-estrella{at}isciii.es


  Abstract

Objective: In vitro susceptibility results of 29 clinical isolates of Rhodotorula spp. were analysed. In addition, the susceptibility profile of another 102 Rhodotorula isolates was reviewed.

Methods: The review included studies using antifungal susceptibility testing reference procedures or commercial methods exhibiting high correlation rates with reference procedures (Etest and Sensititre YeastOne). The 131 organisms analysed were 77 Rhodotorula mucilaginosa, 45 Rhodotorula glutinis and nine Rhodotorula spp.

Results and conclusions: Fluconazole, itraconazole and voriconazole were inactive in vitro against the majority of isolates. Amphotericin B and flucytosine exhibited good activity, being reasonable alternatives for empirical treatment. Ravuconazole was more active in vitro than other azole agents and it could be considered as an extended-spectrum triazole and maybe as a therapeutic alternative in treating infections caused by Rhodotorula species.

Keywords: Rhodotorula; susceptibility of emerging yeasts; fluconazole resistance; ravuconazole.
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