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JAC Advance Access published online on November 10, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh490
© 2004 by The British Society for Antimicrobial Chemotherapy
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Received August 8, 2004
Revised September 30, 2004
Accepted October 1, 2004

Brief report

Plasma levels of zidovudine twice daily compared with three times daily in six HIV-1-infected children

Alina S. Bergshoeff 1, Pieter L. A. Fraaij 2, Corrien Verweij 1, Annemarie M. C. van Rossum 2, Gwenda Verweel 2, Nico G. Hartwig 2, Ronald de Groot 2, and David M. Burger 1*

1 Department of Clinical Pharmacy, University Medical Center, Nijmegen, The Netherlands; Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
2 Department of Pediatrics, Erasmus MC/Sophia, Rotterdam, The Netherlands

* To whom correspondence should be addressed.
David M. Burger, E-mail: D.Burger{at}akf.umcn.nl


  Abstract

Objectives: Zidovudine is often administered every 12 h in HIV-infected children, but so far no pharmacokinetic data are available for the administration of this agent every 12 h. We have evaluated the plasma pharmacokinetics of zidovudine administered every 8 h versus every 12 h in HIV-1-infected children.

Methods: In HIV-1-infected children who switched from zidovudine every 8 h to every 12 h, a pharmacokinetic curve was recorded both before and after the switch. Zidovudine plasma levels were measured by HPLC. Pharmacokinetic parameters were calculated by non-compartmental methods.

Results: Six HIV-1-infected children [median age (range) 7.8 (2.5-13.4) years] were included. In these patients, geometric mean ratios of AUC0-24 and Cmax for zidovudine every 12 h versus every 8 h were not significantly different from 1.0.

Conclusions: The plasma pharmacokinetic parameters of zidovudine taken every 8 h and every 12 h were not significantly different and therefore suggest bioequivalence of these two dose frequencies.

Keywords: pharmacokinetics; paediatrics; pharmacology.
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