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JAC Advance Access published online on September 3, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh414
© 2004 by The British Society for Antimicrobial Chemotherapy
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Received June 30, 2004
Accepted July 24, 2004

Brief report

Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: a randomized, multicentre, open-label, prospective study

José Luis Arredondo-García 1 {dagger}, Ricardo Figueroa-Damián 1, Alejandro Rosas 2, Arturo Jáuregui 3 {ddagger}, Mauricio Corral 4, Alexis Costa 5, Roberto Mauricio Merlos 6, Antonio Ríos-Fabra 7, Carlos F. Amábile-Cuevas 8*, Gerardo M. Hernández-Oliva 9, Jorge Olguín 9, Oscar Cardeñosa-Guerra 10, and on behalf of the uUTI Latin American Study Group {sect}

1 Instituto Nacional de Perinatología, Mexico City, Mexico
2 Hospital General de México, Mexico City, Mexico
3 Hospital Clínica del Parque, Chihuahua, Mexico
4 Hospital Eugenio Espejo, Quito, Ecuador
5 Hospital del Sur, Quito, Ecuador
6 Hospital de Maternidad, San Salvador, El Salvador
7 Hospital Vargas de Caracas, Caracas, Venezuela
8 Fundación Lusara, Apartado Postal 102-006, 08930, Mexico City, Mexico
9 Bayer de México, Dirección Médica, Mexico City, Mexico
10 Química Farmacéutica Bayer, Barcelona, Spain

* To whom correspondence should be addressed. E-mail: carlos.amabile{at}lusara.org.


  Abstract

Objective: To compare the bacteriological and clinical efficacy of three treatments for uncomplicated cystitis in ambulatory pre-menopausal women: ciprofloxacin 250 mg orally twice daily for 3 days, trimethoprim/sulfamethoxazole 160/800 mg orally twice daily for 7 days, and norfloxacin 400 mg orally twice daily for 7 days.

Materials and methods: A total of 455 women were randomly assigned to three treatment groups: 151 received ciprofloxacin, 150 received trimethoprim/sulfamethoxazole, and 154 received norfloxacin. Bacteriological cure and clinical resolution were evaluated 5-9 days and 4-6 weeks after completion of treatment.

Results: There was no significant difference among the three treatment groups: overall efficacy ranged from 78.5% for the trimethoprim/sulfamethoxazole group, to 84.5% for the ciprofloxacin group. The highest overall incidence of drug-related adverse effects occurred in the trimethoprim/sulfamethoxazole patients.

Conclusions: These data indicate that a 3 day treatment with ciprofloxacin is at least as clinically and bacteriologically effective as 7 day treatments with trimethoprim/sulfamethoxazole and norfloxacin for uncomplicated lower urinary tract infections.

Keywords: fluoroquinolones; clinical trials; cystitis; Latin America.

{dagger}Present address. Unidad de Apoyo a la Investigación Clínica, Instituto Nacional de Pediatría, Mexico City, Mexico.

{ddagger}Present address. Hospital CIMA, Chihuahua, Mexico.

{sect}Members of the uUTI Latin American Study Group are listed in the Acknowledgements.


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S. Nys, T. van Merode, A. I. M. Bartelds, and E. E. Stobberingh
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[Abstract] [Full Text] [PDF]


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