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JAC Advance Access published online on July 8, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh349
© 2004 by The British Society for Antimicrobial Chemotherapy
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Received May 9, 2004
Revised May 31, 2004
Accepted June 3, 2004

Brief report

Anomaly and correlation of killing in the therapeutic properties of silver (I) chelation with glutamic and tartaric acids

Kareen I. Batarseh 1*

1 Alpha-OmegaBiologicals, 8610 Larkview Lane, Fairfax Station, VA 22039, USA

* To whom correspondence should be addressed. E-mail: fractals00{at}hotmail.com/fractals00@aobio.com.


  Abstract

Objectives: To investigate whether silver chelates or silver ions are more effective as therapeutic agents, and to examine their mode of action so that safer and stable compounds that have a broad spectrum of therapeutic activities can be developed.

Methods: Efficacy was investigated against Pseudomonas aeruginosa (ATCC 15442) by determining MIC via a broth macrodilution procedure using NCCLS methods for antibiotic susceptibility testing.

Results: It was found that the responsible agent for silver therapeutic properties is the silver chelates rather than silver ions, contradicting previous findings, and the efficacy profiles mimic that of free silver ions present in solution.

Conclusions: Silver therapeutic activities seem to be more effective as complexes--an intracellular package--rather than free silver ions, demonstrating that the effect of silver is linked to cells' DNA unwinding, and not respiratory or membrane functionality as was traditionally recognized.

Keywords: oligodynamics; silver; antimicrobials; chemotherapeutics; DNA.
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