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JAC Advance Access published online on May 26, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh254
© 2004 by The British Society for Antimicrobial Chemotherapy
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Received December 23, 2003
Revised March 24, 2004
Accepted April 1, 2004

Original article

Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm

Doron Steinberg 1*, Mark Feldman 2, Itzhak Ofek 3, Ervin I. Weiss 4

1 Institute of Dental Sciences, Hebrew University-Hadassah, PO Box 12272, Jerusalem, 91120, Israel
2 Institute of Dental Sciences and Department of Prosthodontics, Faculty of Dentistry, Hebrew University-Hadassah, PO Box 12272, Jerusalem, 91120, Israel
3 Department of Human Microbiology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
4 Department of Prosthodontics, Faculty of Dentistry, Hebrew University-Hadassah, PO Box 12272, Jerusalem, 91120, Israel

* To whom correspondence should be addressed. E-mail: dorons{at}cc.huji.ac.il.


  Abstract

Background: Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria.

Objectives: In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus.

Results: The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05).

Conclusions: Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.

Key Words: Keywords: mutans streptococci, anti-adhesion, glucosyltransferases, fructosyltransferases


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