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JAC Advance Access published online on April 21, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh228
© 2004 by The British Society for Antimicrobial Chemotherapy
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Received November 18, 2003
Revised December 23, 2003
Accepted March 8, 2004

Brief report

In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi

Guillermo Garcia-Effron 1, Alicia Gomez-Lopez 1, Emilia Mellado 1, Araceli Monzon 1, Juan L. Rodriguez-Tudela 1, Manuel Cuenca-Estrella 1*

1 Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda, Madrid, Spain

* To whom correspondence should be addressed. E-mail: mcuenca-estrella{at}isciii.es.


  Abstract

Objectives: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed.

Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously.

Results: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. However, some species such as Scedosporium spp., Fusarium spp., Scopulariopsis brevicaulis, and most of Mucorales exhibited high MICs of the allylamine with GMs >= 4 mg/L.

Conclusions: Overall, the GM of MICs of terbinafine was 1.57 mg/L, but significant differences in susceptibilities were seen between genera and species.

Key Words: Keywords: Aspergillus spp., Spanish filamentous fungi, allylamines, antifungals


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