JAC Advance Access published online on April 8, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh211
© 2004 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Department of Specific
Prophylaxis and Tropical Medicine, Institute of Pathophysiology,
Medical University Vienna, Kinderspitalgasse 15, A-1095 Vienna;
* Corresponding author. E-mail: apostolos.georgopoulos{at}meduniwien.ac.at.
Received 19 November 2003
; revised 16 February 2004
; accepted 28 February 2004
Objectives: This study was undertaken
to analyse incidence rates, serotype distribution and antimicrobial resistance
patterns of invasive Streptococcus pneumoniae isolates
from hospitalized children up to 5 years of age with invasive pneumococcal
disease (IPD), including meningitis, in Austria. Methods: From February 2001-January
2003, nationwide prospective surveillance was conducted that included
all paediatric hospitals and clinical microbiological laboratories.
All invasive pneumococci isolated were serotyped and tested for
antimicrobial susceptibility. Results: The mean annual incidence rates of
IPD per 10 000 population for the age groups <24 months
and <60 months were 14.5 (7.7 for meningitis) and 13.7
(6.0 for meningitis), respectively. The case fatality rate was 6% for
IPD and 12% for meningitis. Of all IPD cases, 69.6% (73.1% for
meningitis) were covered by serotypes and 83.9% (88.5% for
meningitis) by cross-protection of vaccine-related serotypes. Intermediate penicillin
G susceptibility (MIC 0.12-1 mg/L) was found in 12/56 strains.
No penicillin G-resistant strains were found. A total of 19/56 isolates
showed decreased susceptibility to macrolide agents (MIC Conclusions: The IPD incidence rate was similar,
and serotype coverage of the 7-valent conjugated vaccine marginally
superior, to Germany. The surprisingly high level of antimicrobial
resistance among invasive isolates considerably amplifies the potential
impact of a childhood pneumococcal vaccination programme in Austria.
Keywords: S. pneumoniae, incidence, serotype
coverage, susceptibilities
Prospective surveillance of incidence, serotypes
and antimicrobial susceptibility of invasive Streptococcus
pneumoniae among
hospitalized children in Austria
2 University Clinic for Internal
Medicine I, Clinical Department for Infectious Diseases and Chemotherapy,
Medical University Vienna,
Währinger Gürtel 18-20, A-1090 Vienna;
3 Institute of Environmental Health,
Medical University Vienna;
4 Children’s
Hospital Leoben, Leoben;
5 Wyeth
Lederle Pharma GmbH, Vienna;
6 St Anna Children’s Hospital,
Vienna, Austria
1
mg/L).
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