JAC Advance Access published online on April 21, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh182
© 2004 by The British Society for Antimicrobial Chemotherapy
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1 Centre for Epidemiology
and Risk Analysis, Veterinary Laboratories Agency--Weybridge,
New Haw,
Addlestone, Surrey KT15 3NB;
* To whom correspondence should be addressed. E-mail: e.l.snary{at}vla.defra.gsi.gov.uk.
The emergence of antimicrobial-resistant microorganisms
in both humans and food animals is a growing concern. Debate has
centred on links between antimicrobial use in the production of
food animals and the emergence of resistant organisms in the human
population. Consequently, microbial risk assessment (MRA) is being
used to facilitate scientific investigations of the risks related
to the food chain, including quantification of uncertainty and prioritization
of control strategies. MRA is a scientific tool that can be used to
evaluate the level of exposure and the subsequent risk to human
health relating to a specific organism or particular type of resistance.
This paper reviews the recent applications of MRA in the area of
antimicrobial resistance, and in particular, it focuses on the methods,
assumptions and data limitations. Since MRA outputs are dependent
on the quality of data inputs used in their development, we aim
to promote the generation of good quality data by describing the
properties that data should ideally possess for MRA and by highlighting
the benefit of data generation specifically for inclusion in MRAs.
Review
Antimicrobial resistance: a microbial risk assessment
perspective
2 Centre for Epidemiology
and Risk Analysis, Veterinary Laboratories Agency--Weybridge,
New Haw,
Addlestone, Surrey KT15 3NB; Department
of Statistics and Modelling Science, University of Strathclyde, Richmond
St, Glasgow G1 1XH;
3 Veterinary
Laboratories Agency--Shrewsbury, Kendal Road, Harlescott, Shrewsbury,
Shropshire SY1 4HD, UK
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