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JAC Advance Access published online on April 8, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh171
© 2004 by The British Society for Antimicrobial Chemotherapy
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© 2004 The British Society for Antimicrobial Chemotherapy

Leading article

Whither triclosan?

A. D. Russell 1 *

1 Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, UK

* Corresponding author. E-mail: russellD2{at}cardiff.ac.uk.

Abstract

Triclosan has activity against many, but not all, types of Gram-positive and Gram-negative bacteria. It is bacteriostatic at low concentrations, but higher concentrations are bactericidal. Pseudomonas aeruginosa is highly resistant, whereas methicillin-resistant Staphylococcus aureus strains are inhibited over a range of ~0.1-2 mg/L. Triclosan shows significant activity against some mycobacteria, but is not sporicidal. Its growth-inhibitory properties result from an inhibition of enoyl reductase, FabI. Membrane-destabilizing effects are likely to be responsible for bacterial inactivation by higher concentrations. Resistance can arise from mutations in, and/or overproduction of, FabI, impermeability or efflux. Whilst triclosan resistance in laboratory experiments may be associated with changes in antibiotic susceptibility, comprehensive environmental surveys have not demonstrated any association between triclosan usage and antibiotic resistance. Triclosan has several important uses, and the future aim must be to retain these applications whilst eliminating the more frivolous and unnecessary ones.

Keywords: mechanisms of action, mechanisms of resistance, antibiotic resistance
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