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JAC Advance Access published online on March 24, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh161
© 2004 by The British Society for Antimicrobial Chemotherapy
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© 2004 The British Society for Antimicrobial Chemotherapy

Leading article

Clinical perspective of fusion inhibitors for treatment of HIV

J. K. Rockstroh 1 * and S. Mauss 2

1 Department of Medicine I, University of Bonn, Bonn;
2 Center for HIV and Hepatogastroenterology, Düsseldorf, Germany

* Corresponding author. E-mail: rockstroh{at}uni-bonn.de.

Abstract

The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options for this specific group of patients are limited. The fusion inhibitor enfuvirtide represents the first new therapeutic option from a new drug class for this patient population. An optimized background therapy with remaining antiviral activity appears essential in order to avoid resistance development against enfuvirtide. Despite the high price of enfuvirtide, cost-effectiveness and increase in quality of life have been demonstrated in patients achieving virological control under optimized background and enfuvirtide therapy. In this article, the characteristics and clinical perspectives of fusion inhibitors are presented and discussed.

Keywords: antiretroviral therapy, enfuvirtide, HAART, salvage therapy
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