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JAC Advance Access published online on March 10, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh157
© 2004 by The British Society for Antimicrobial Chemotherapy
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© 2004 The British Society for Antimicrobial Chemotherapy

Leading article

Benefits and limitations of testing for resistance to HIV drugs

Douglas D. Richman 1 *

1 Veterans Affairs San Diego Healthcare System and University of California San Diego, Departments of Pathology and Medicine, 0679, 9500 Gilman Drive, La Jolla, CA 92093-0679, USA

* Corresponding author. E-mail: drichman{at}ucsd.edu.

Abstract

Since drug resistance was first described in HIV in 1989, great progress has been made in our understanding of its genetic basis and molecular mechanisms. Despite these advances and the introduction of many new antiretroviral drugs, resistance remains prevalent. The types of drug resistance tests and their relative advantages and disadvantages are reviewed. How and when these tests should be used to inform HIV clinical practice and their place in anti-HIV drug development are considered.

Keywords: antiretroviral drugs, HIV drug resistance, resistance testing
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