JAC Advance Access published online on March 10, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh146
© 2004 by The British Society for Antimicrobial Chemotherapy
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Brief report
1 Department of Clinical
Pharmacology, Christchurch Hospital, Christchurch, New
Zealand;
* Corresponding author. E-mail: janevb{at}cdhb.govt.nz.
Received 31 August 2003
; revised 15 January 2004
; accepted 16 January 2004
Objectives: The aim of this study
was to investigate the temperature profile of home intravenous (iv)
antibiotic reservoirs and the stability of 16 megaunits of benzylpenicillin
sodium in 120 mL of sodium chloride 0.9% at constant and
variable temperatures. Methods: A Tinytag computerized thermometer
recorded temperatures every minute in the home iv antibiotic reservoir
pouches of nine patients over a 24 h period. Similar bags containing
benzylpenicillin sodium (16 megaunits) were maintained either at
a constant 36°C, 26°C
or 21-22°C or were worn in
a pouch by five healthy volunteers for a 24 h period. Other bags
were stored at 3-5°C for 10
days. The bags were sampled at timed intervals and benzylpenicillin
concentrations assayed by HPLC. Results: Median temperatures recorded in the
infusion bags worn by the nine patients were in the range 16.7-34.1°C. For infusion bags maintained at
36°C, 26°C
and 21-22°C, the concentrations
of benzylpenicillin dropped below 90% of the initial concentration
at a mean time of 5 h 18 min, 12 h 54 min and 13 h 20 min, respectively,
whereas for bags worn by the healthy volunteers the mean time for
10% loss of benzylpenicillin was 9 h 20 min. In contrast,
at 3-5°C, concentrations of
benzylpenicillin only dropped below 90% of the initial concentration
at 8 days. Conclusions: Significant temperature-dependent
degradation of benzylpenicillin occurs during continuous home iv
antibiotic programme infusions, which could result in loss of efficacy.
Keywords: benzylpenicillin, home iv therapy, stability,
temperature
Stability of benzylpenicillin during continuous
home
intravenous therapy
2 Department
of Infectious Diseases, Christchurch Hospital, Christchurch, New
Zealand;
3 Department of Clinical
Pharmacology, Christchurch Hospital, Christchurch, New
Zealand; School of Pharmacy,
University of Queensland, Queensland, Australia
4 Department of Medicine, Christchurch School of Medicine, Otago University, Christchurch,
New Zealand;
5 Department
of Infectious Diseases, Christchurch Hospital, Christchurch, New
Zealand; Department of Pathology,
Christchurch School of Medicine, Otago University, Christchurch,
New Zealand;
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