JAC Advance Access published online on February 25, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh143
© 2004 by The British Society for Antimicrobial Chemotherapy
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Brief reports
1 The JONES Group/JMI Laboratories,
Inc., 345 Beaver Kreek Centre, Suite A, North Liberty,
Iowa 52317;
* Corresponding author. E-mail: helio-sader{at}jmilabs.com.
Received 21 October 2003
; revised 8 January 2004
; accepted 15 January 2004
Background: Increasing antimicrobial
resistance among bacterial pathogens has prompted attempts to develop
new antimicrobial agents active against multidrug-resistant Gram-positive
pathogens. Objectives: To evaluate the in vitro activity
of daptomycin against a worldwide collection of clinical bacterial isolates. Methods: Daptomycin is a novel cyclic lipopeptide
recently approved by the United States Food and Drug Administration.
Daptomycin and selected comparators were tested against 6737 clinical
Gram-positive strains from more than 70 centres located in Europe,
North America and South America. Results: The overall distribution of daptomycin
MIC values were in the range Conclusions: Daptomycin exhibited excellent in vitro activity against a wide spectrum of Gram-positive organisms
and may represent a therapeutic option for infections caused by
multidrug-resistant pathogens worldwide.
Keywords: resistance, glycopeptides, multidrug-resistant
Daptomycin activity and spectrum: a worldwide sample
of
6737 clinical Gram-positive organisms
2 The JONES Group/JMI Laboratories,
Inc., 345 Beaver Kreek Centre, Suite A, North Liberty,
Iowa 52317; Tufts University
School of Medicine, Boston, MA, USA
0.12-8
mg/L and 99.4% of all strains were inhibited at 2
mg/L. Despite resistances to other antimicrobial agents, >99.9% of
staphylococcal isolates were inhibited at 1
mg/L of daptomycin (MIC90 0.5 mg/L for staphylococci).
Streptococcal isolates were very susceptible to daptomycin independent
of their susceptibility to penicillin. MIC50/90 values were 0.12 and 0.25 mg/L, respectively. Enterococci
showed the highest daptomycin MIC values, but all isolates tested
were inhibited at 4 mg/L (except for
one Enterococcus faecium isolate which showed a daptomycin
MIC of 8 mg/L).
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