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JAC Advance Access published online on February 25, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh132
© 2004 by The British Society for Antimicrobial Chemotherapy
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© 2004 The British Society for Antimicrobial Chemotherapy

Review

Role of therapeutic vaccines in the control of HIV-1

S. Kinloch-de Loes 1 *

1 Department of HIV/Thoracic Medicine, Department of Medicine and Department of Immunology and Molecular Pathology, The Royal Free Centre for HIV Medicine, Royal Free Campus, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK

* Corresponding author. E-mail: sabine{at}kinloch.u-net.com.

Abstract

The recent success of highly active antiretroviral therapy (HAART) has altered the prognosis of patients living with HIV-1 infection. However, there are still many challenges to be addressed if we want to develop long-term therapeutic strategies for patients, in both the Western world and resource-poor countries. In this review, the potential role for HIV-1 therapeutic vaccines in the era of HAART will be discussed in the light of the present efforts at developing immune-based therapies to complement antiviral treatment and minimize the duration of exposure to antiviral drugs.

Keywords: immune control, immune-based therapies, HIV, highly active antiretroviral therapy
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