JAC Advance Access published online on February 12, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh110
© 2004 by The British Society for Antimicrobial Chemotherapy
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brief report
1 Department of Anaesthesiology
and Intensive Care, Hôtel-Dieu Hospital, Lyon;
* Corresponding author. E-mail: emmanuel.boselli{at}chu-lyon.fr.
Received 13 August 2003
; revised 4 December 2003
; accepted 13 December 2003
Objectives: The degree of penetration
of an antibiotic into the infected site is an important determinant
of therapeutic success. Levofloxacin is widely used in the treatment
of serious infections. However, there are only few studies concerning
its diffusion into bone tissue and none concerning its diffusion
into synovial tissue. Our objective was to quantify levofloxacin
bone and synovial tissue penetration and to compare our data with
the breakpoint for susceptible organisms. Patients and methods: In an open-label study,
12 subjects who were undergoing elective total hip replacement received
a single, parenteral, 500 mg dose of levofloxacin. Plasma, cortical
and cancellous bone, and synovial tissue samples were collected
a mean of 1.2 h later and analysed by a validated HPLC method. Results: The mean ± S.D. plasma concentration of levofloxacin
at the time of bone removal was 7.5 ± 1.3
mg/L. The levofloxacin concentrations were 7.4 ± 2.2
mg/kg in cancellous bone tissue and 3.9 ± 1.2
mg/kg in cortical bone tissue. The levofloxacin concentration was
8.9 ± 2.1 mg/kg in synovial tissue.
The mean ± S.D.
ratios of levofloxacin concentration in bone and plasma (bone/plasma)
were 1.0 ± 0.4 for cancellous bone tissue and
0.5 ± 0.1 for cortical bone tissue.
The ratio of levofloxacin concentration in synovial tissue and plasma (synovial
tissue/plasma) was 1.2 ± 0.4. Conclusions: The concentrations of levofloxacin
achieved in cancellous and cortical bone tissue and in synovial
tissue are greater than the breakpoint for susceptible organisms,
which is
Keywords: levofloxacin, diffusion, bone and synovial tissues,
pharmacokinetics, bone and joint infections
Diffusion of levofloxacin into bone and synovial
tissues
2 Clinical Pharmacokinetics Laboratory,
Haut-Lévêque Hospital, Pessac; Departments of
3 Department of Orthopaedic Surgery, Edouard Herriot Hospital, Lyon, France
4 Department of Anaesthesiology and Intensive Care,
Edouard Herriot Hospital, Lyon, France
2 mg/L.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. C. Martinez-Pastor, E. Munoz-Mahamud, F. Vilchez, S. Garcia-Ramiro, G. Bori, J. Sierra, J. A. Martinez, L. Font, J. Mensa, and A. Soriano Outcome of Acute Prosthetic Joint Infections Due to Gram-Negative Bacilli Treated with Open Debridement and Retention of the Prosthesis Antimicrob. Agents Chemother., November 1, 2009; 53(11): 4772 - 4777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Denes, A. Boumediene, H. Durox, A. Oksman, F. Saint-Marcoux, M.-L. Darde, and J.-M. Gaulier Voriconazole concentrations in synovial fluid and bone tissues J. Antimicrob. Chemother., April 1, 2007; 59(4): 818 - 819. [Full Text] [PDF]
|
|