JAC Advance Access published online on February 18, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh109
© 2004 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Microbiology Service,
Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián
(Gipuzkoa); Department of
Preventive Medicine and Public Health, Faculty of Medicine, University
of the Basque Country,
San Sebastián, Spain
* Corresponding author. E-mail: mikrobiol{at}terra.es.
Received 4 November 2003
; revised 10 December 2003
; accepted 11 December 2003
Objective: To study the characteristics
and the evolution through time of a single Streptococcus
pneumoniae multidrug-resistant international clone. Methods: From 1981 to 2002, the presence of
the multidrug-resistant Spain14-5 clone was studied among
the 4201 S. pneumoniae isolated in Gipuzkoa (northern
Spain). Results: Overall, 93 isolates belonging to the
Spain14-5 clone were identified. The first isolate of
this clone was detected in 1981 and was already resistant to Conclusions: The clone was genetically stable
through time, was multiresistant since its inception and has recently
become highly resistant to fluoroquinolones. The characteristic
antibiotic resistance pattern of this clone should include erythromycin
resistance.
Keywords: multiresistance, PFGE, MLST, fluoroquinolone
resistance, macrolide resistance
Spectrum of antibiotic resistance of the Spain14-5
Streptococcus pneumoniae clone over a 22 year period
2 Microbiology Service,
Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián
(Gipuzkoa);
-lactams, erythromycin, clindamycin
and chloramphenicol. The reference strain from the international
collection for this clone was susceptible to macrolides and lincosamides
whereas most of the isolates studied, including the first isolate
detected in 1981, were resistant to macrolides and had the erm(B)
gene encoding macrolide resistance.
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