Skip Navigation



JAC Advance Access published online on January 28, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh102
© 2004 by The British Society for Antimicrobial Chemotherapy
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
53/3/469    most recent
dkh102v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Scott, P.
Right arrow Articles by Pillay, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scott, P.
Right arrow Articles by Pillay, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2004 The British Society for Antimicrobial Chemotherapy

Original article

Surveillance of HIV antiretroviral drug resistance in treated individuals in England: 1998-2000

Paul Scott 1 , Eve Arnold 2 , Barry Evans 3 , Anton Pozniak 4 , Graeme Moyle 4 , Mohsen Shahmenesh 5 , David White 6 , Jane Shirley 1 , Patricia Cane 1 , and Deenan Pillay 1 *

1 PHLS Antiviral Susceptibility Reference Unit, Birmingham;
2 Statistics Unit, Communicable Disease Surveillance Centre, Colindale, London;
3 HIV Division, Communicable Disease Surveillance Centre, Colindale, London;
4 Department of HIV and GUM, Chelsea and Westminster Hospital, London;
5 University Hospital NHS Trust Birmingham, Birmingham;
6 Department of Sexual Medicine, Birmingham Heartlands Hospital, Birmingham, UK

* Corresponding author. E-mail: D.Pillay{at}ucl.ac.uk.

Received 20 May 2003 ; revised 7 November 2003 ; accepted 8 December 2003

Abstract

Objectives: To establish a surveillance programme for HIV drug resistance within the UK covering the years from 1998 to 2000, following the introduction of triple combination antiretroviral therapy.

Methods: Sentinel sites included large, medium sized and small clinical centres. Data were analysed until December 2000.

Results: Of nearly 300 samples tested, results from 91, 92 and 92 patients, respectively in 1998, 1999 and 2000, who were receiving HIV therapy with a viral load >2000 copies/mL, the majority had viruses with some degree of drug resistance. Overall, the presence of any resistance increased between 1998 and 1999, and fell again in 2000 (69% versus 88% versus 55%). However, major differences were observed between drug classes, such that non-nucleoside analogue reverse transcriptase inhibitor (NNRTI) resistance rose dramatically over the period studied. We show that this correlated with increased NNRTI prescribing. Furthermore, an overall increase in prevalence of viruses with resistance to one or more drugs within all three available classes was observed. A higher prevalence of drug resistance was observed in patients from smaller clinical centres.

Conclusions: This is the first such sentinel surveillance dataset from the UK, and is unique in correlating these data with national antiretroviral prescribing patterns. Our findings are relevant to the increased transmission of HIV drug resistance observed over this period.

Keywords: HIV-1, resistance, surveillance
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Sex. Transm. Infect.Home page
A E Brown, S E Tomkins, L E Logan, D S LaMontagne, H L Munro, V D Hope, A Righarts, J E Blackham, B D Rice, T R Chadborn, et al.
Monitoring the effectiveness of HIV and STI prevention initiatives in England, Wales, and Northern Ireland: where are we now?
Sex Transm Inf, February 1, 2006; 82(1): 4 - 10.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.