JAC Advance Access published online on January 28, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh099
© 2004 by The British Society for Antimicrobial Chemotherapy
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Brief report
1 Laboratoire de Parasitologie et Mycologie Médicales,
Centre Hospitalier Universitaire La Milétrie, BP 577,
86021 Poitiers Cedex, France
* Corresponding author. E-mail: Christine.Imbert{at}univ-poitiers.fr.
Received 12 September 2003
; revised 19 November 2003
; accepted 6 December 2003
Objectives: Some manifestations of
candidiasis are associated with the formation of biofilms on inert
or biological surfaces and the intrinsic resistance of Candida
albicans biofilms to the most commonly used antifungal agents
has been demonstrated. In this study, we report on the influence
of the growth of C. albicans in medium containing
a sub-inhibitory concentration (MIC/2) of caspofungin, on subsequent
fungal adherence to plastic coated with extracellular matrix (ECM)
proteins. Methods: Eleven strains of C. albicans were
studied: six strains were susceptible to fluconazole in
vitro and five strains were resistant to this antifungal agent. Results: Caspofungin induced a decrease in the
adherence of all the tested strains that were susceptible to fluconazole
but induced a decrease in the adherence of only 60% of
the fluconazole-resistant strains. Conclusions: This study demonstrated the anti-adherent
activity of caspofungin but indicated a reduced effect in the case
of in vitro fluconazole resistance. These results
indicated a possible relationship between the efficiency of caspofungin
to inhibit the first step of the development of C. albicans biofilm
and the resistance of C. albicans to fluconazole in vitro.
Keywords: yeast, adhesion, antifungal agents, candidiasis
Caspofungin modulates in vitro adherence
of Candida albicans to plastic coated with extracellular
matrix proteins
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