JAC Advance Access published online on January 16, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh070
© 2004 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Food and Environmental
Safety Department, Veterinary Laboratories Agency (Weybridge), New
Haw, Addlestone, Surrey KT15 3NB;
* Corresponding author. E-mail: l.randall{at}vla.defra.gsi.gov.uk.
Received 8 September 2003
; revised 12 November 2003
; accepted 13 November 2003
Objectives: To examine 397 strains
of Salmonella enterica of human and animal origin
comprising 35 serotypes for the presence of aadB, aphAI-IAB,
aadA1, aadA2, bla(Carb2) or pse1, bla(Tem),
cat1, cat2, dhfr1, floR, strA, sul1, sul2, tetA(A), tetA(B) and tetA(G) genes, the presence of class 1 integrons
and the relationship of resistance genes to integrons and antibiotic
resistance. Results: Some strains were resistant to ampicillin
(91), chloramphenicol (85), gentamicin (2), kanamycin (14), spectinomycin
(81), streptomycin (119), sulfadiazine (127), tetracycline (108)
and trimethoprim (45); 219 strains were susceptible
to all antibiotics. bla(Carb2), floR and tetA(G) genes were
found in S. Typhimurium isolates and one strain
of S. Emek only. Class 1 integrons were found in S. Emek, Haifa, Heidelberg, Mbandaka, Newport,
Ohio, Stanley, Virchow and in Typhimurium, mainly phage types DT104
and U302. These strains were generally multi-resistant to up to
seven antibiotics. Resistance to between three and six antibiotics
was also associated with class 1 integron-negative strains of S. Binza, Dublin, Enteritidis, Hadar, Manhattan,
Mbandaka, Montevideo, Newport, Typhimurium DT193 and Virchow. Conclusion: The results illustrate specificity
of some resistance genes to S. Typhimurium or non-
S. Typhimurium
serotypes and the involvement of both class 1 integron and non-class
1 integron associated multi-resistance in several serotypes. These
data also indicate that the bla(Carb2), floR and tetA(G) genes reported
in the SG1 region of S. Typhimurium DT104, U302
and some other serotypes are still predominantly limited to S. Typhimurium
strains.
Keywords: Typhimurium, plasmids, ampicillin, streptomycin,
tetracycline
Antibiotic resistance genes, integrons and multiple
antibiotic resistance in thirty-five serotypes of Salmonella
enterica isolated from humans and animals in the UK
2 Antimicrobial Agents Research Group, Division of
Immunity and Infection, The Medical School, University of Birmingham,
Edgbaston, Birmingham B15 2TT, UK
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