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JAC Advance Access published online on January 16, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh068
© 2004 by The British Society for Antimicrobial Chemotherapy
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© 2004 The British Society for Antimicrobial Chemotherapy

Review

Tissue kinetics of telithromycin, the first ketolide antibacterial

C. Muller-Serieys 1 *, J. Andrews 2 , F. Vacheron 3 , and C. Cantalloube 3

1 Hôpital Bichat Claude Bernard, 75877 Paris Cedex 18;
2 City Hospital Birmingham, Birmingham, UK
3 Aventis, Romainville Cedex, France;

* Corresponding author. E-mail: claudette.muller{at}bch.ap-hop-paris.fr.

Received 22 July 2003 ; revised 3 November 2003 ; accepted 13 November 2003

Abstract

The potential efficacy of an antibacterial depends not only on its spectrum of activity but also on its concentration at the site of infection. The tissue kinetics of telithromycin--the first ketolide antibacterial--are reviewed here. Telithromycin accumulates rapidly in white blood cells, inflammatory fluid, and cells and tissues of the upper and lower respiratory tract, with mean concentrations above the MICs of key respiratory pathogens. Tissue kinetics of telithromycin support facilitated delivery to the site of infection, good efficacy against intracellular respiratory pathogens and respiratory pathogens at extracellular sites in the airways, and effectiveness in the treatment of upper and lower respiratory tract infections (RTIs). The tissue kinetics profile of telithromycin, together with its microbiological profile, makes it a promising new antibacterial for the treatment of community-acquired RTIs.

Keywords: antibacterial, ketolide, telithromycin, tissue kinetics
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