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JAC Advance Access published online on January 16, 2004
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh067
© 2004 by The British Society for Antimicrobial Chemotherapy
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© 2004 The British Society for Antimicrobial Chemotherapy

Brief report

In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples

C. Padilla 1 *, O. Lobos 1 , P. Brevis 1 , P. Abaca 1 , and E. Hubert 2

1 Laboratorio de Investigación Microbiológica, Universidad de Talca, Talca, Chile
2 Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Talca, Chile

* Corresponding author. E-mail: cpadilla{at}utalca.cl.

Received 25 July 2003 ; revised 30 September 2003 ; accepted 12 November 2003

Abstract

Objective: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples.

Methods: The qualitative disc diffusion method and MIC determinations were used.

Results: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis.

Conclusions: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.

Keywords: antibiotics, multiresistance and human infections
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