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JAC Advance Access published online on December 4, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkh010
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Leading article

All for CD91 and CD91 for all

Justin Stebbing 1 *, Philip Savage 2 , Steve Patterson 1 , and Brian Gazzard 1

1 Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK;
2 Department of Oncology, Velindre Hospital, Cardiff, Wales, UK

* Corresponding author. E-mail: j.stebbing{at}imperial.ac.uk.

Abstract

Heat shock proteins interact with antigen-presenting cells through their receptor, CD91, eliciting a cascade of events including maturation, activation and representation of chaperoned foreign peptides with class I molecules on their surface. In turn, this facilitates recognition of non-self leading to induction of a cytotoxic T cell response. The abundance of heat shock proteins in tumours and their presence in virion coats makes them attractive propositions for use in antitumour and antiviral strategies.

Keywords: heat shock proteins, HIV, cancer, receptors
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