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JAC Advance Access published online on December 4, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg472
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

Reversible dilated cardiomyopathy related to amphotericin B therapy

Patrick J. Danaher 1 *, Michael K. Cao 2 , Gregory M. Anstead 3 , Matthew J. Dolan 4 , and Caroline C. DeWitt 4

1 Department of Infectious Diseases, David Grant USAF Medical Center, Travis AFB, CA 94535
2 Department of Cardiology, David Grant USAF Medical Center, Travis AFB, CA 94535
3 Medical Service, Department of Veterans Affairs Medical Center, South Texas Health Care System, San Antonio, TX 78229;
4 Department of Infectious Diseases,Wilford Hall USAF Medical Center, Lackland AFB, TX 78236, USA

* Corresponding author. E-mail: patrick.danaher{at}60mdg.travis.af.mil.

Received 17 June 2003 ; revised 3 September 2003 ; accepted 15 September 2003

Abstract

We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities and heart failure resolved after posaconazole was substituted for AmB. It is important to recognize the rare and potentially reversible toxicity of AmB.

Keywords: posaconazole, coccidioidomycosis, Coccidioides immitis
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