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JAC Advance Access published online on October 16, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg452
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

Chloramphenicol-resistant Neisseria meningitidis containing catP isolated in Australia

Tiffany R. Shultz 1 , John W. Tapsall 1 *, Peter A. White 2 , Catherine S. Ryan 3 , Dena Lyras 3 , Julian I. Rood 3 , Enzo Binotto 4 , and Christopher J. L. Richardson 5

1 Department of Microbiology, South Eastern Sydney Area Health Services, The Prince of Wales Hospital, Sydney 2031;
2 School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney 2052;
3 Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University 3800;
4 Department of Microbiology and Infectious Diseases, South West Area Pathology Service, Locked Bag 7090 Liverpool BC 1871, Australia;
5 Department of Microbiology, Women’s & Children’s Health Services (WA); Princess Margaret Hospital, GPO Box D184, Perth, Western Australia 6001

* Corresponding author. E-mail: j.tapsall{at}unsw.edu.au.

Received 9 June 2003 ; revised 19 August 2003 ; accepted 22 August 2003

Abstract

Earlier workers have described chloramphenicol resistance in meningococci isolated from cerebrospinal fluid sampled in patients in Vietnam (11 cases) and France (one case) during 1987-1996. Here we describe two distinct serogroup B strains isolated in Australia in 1994 and 1997, and found among ~1400 invasive meningococcal isolates examined in Australia over a 9 year period. Both were phenotypically chloramphenicol resistant on disc, Etest and agar inclusion MIC and acetylated chloramphenicol examination. DNA amplification and sequencing confirmed the presence of catP and the 3' end of tnpV from Tn4451, a mobilizable element from Clostridium perfringens, although other sequences were not present. Tn4451 has inserted into a gene designated TIGR locus NMB1350 in both isolates with no loss of DNA and no apparent interruption of virulence genes. This second report of chloramphenicol-resistant meningococci is in a setting with a very low volume of systemic chloramphenicol use, but where the high topical use may contribute to recombination events in vivo. Methods for screening for chloramphenicol resistance in meningococci and the in vitro parameters that define this resistance are ill defined.

Keywords: N. meningitidis, chloramphenicol resistance, antibiotic use, chloramphenicol acetyltransferase, transposons
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