JAC Advance Access published online on September 12, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg426
© 2003 by The British Society for Antimicrobial Chemotherapy
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Brief report
1 WHO Collaborating Centre
for Antimicrobial Resistance in Bacteria from Food animals and Food
of Animal Origin, Danish Veterinary Institute, Bülowsvej
27, DK-1790 Copenhagen V, Denmark
* Corresponding author. E-mail: faa{at}vetinst.dk.
Received 16 June 2003
; revised 17 July 2003
; accepted 23 July 2003
Objectives: This study was conducted
to investigate the occurrence of antimicrobial resistance among Salmonella Weltevreden isolates from different
sources in South-East Asia (Indonesia, Laos, Malaysia, Taiwan, Thailand,
Vietnam), Australia, Denmark, New Zealand and the USA. Methods: A total of 503 isolates were examined
for susceptibility to antimicrobial agents, and resistant isolates
were examined for the presence of selected resistance genes by PCR. Results: Only 48 (9.5%) of the isolates
were resistant to one or more of the antimicrobial agents tested.
A low frequency of resistance was found towards ampicillin (1.8%),
chloramphenicol (1.6%), florphenicol (0.4%), nalidixic
acid (1.6%), neomycin (0.6%), streptomycin (4.4%),
sulfamethoxazole (4.2%), tetracycline (4.0%) and
trimethoprim (1.4%), whereas all isolates were susceptible
to co-amoxiclav, ceftiofur, ciprofloxacin, colistin and gentamicin.
All nine ampicillin-resistant isolates contained a sequence similar
to the blaTEM-1b gene, one of the eight
chloramphenicol-resistant isolates a sequence similar to the catA1 gene,
all three neomycin-resistant isolates a sequence similar to the aphA-2 gene, 16 (73%) of the 22 streptomycin-resistant
isolates a sequence similar to the aadA gene, the
remaining six (27%) a sequence similar to the strA gene,
and all 21 sulfamethoxazole-resistant isolates a sequence similar
to the sul2 gene. Thirteen (65%) of the
20 tetracycline-resistant isolates contained the tet(A)
gene, four (20%) the tet(B) gene, and
one (5%) the tet(C) gene. Conclusions: This study showed a low frequency
of resistance among Salmonella Weltevreden isolated from
humans and other reservoirs in South-East Asia and elsewhere. There
was no major difference in the occurrence of resistance between
source or geographical origin.
Keywords: Salmonella Weltevreden, antimicrobial
resistance, genes, South-East Asia
Antimicrobial susceptibility and occurrence of
resistance genes among Salmonella enterica serovar
Weltevreden from different countries
2 Center for Antimicrobial Resistance Monitoring
in Food-borne Pathogens, Faculty of Veterinary Science, Chulalongkorn
University, Bangkok
3 WHO
International Salmonella and Shigella Centre, National Institute
of Health, Department of Medical Sciences, Ministry of Public Health,
Bangkok, Thailand
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