JAC Advance Access published online on September 1, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg396
© 2003 by The British Society for Antimicrobial Chemotherapy
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Brief report
1 Institute of Infectious
Diseases and Public Health, University of Ancona, Ancona
* Corresponding author. E-mail: anconacmi{at}interfree.it.
Received 27 March 2003
; revised 20 June 2003
; accepted 29 June 2003
Objectives: A rat model was used to
investigate the efficacy of linezolid, alone or in combination with
levofloxacin and vancomycin, in the prevention of vascular prosthetic
graft infection resulting from methicillin-resistant Staphylococcus
epidermidis with intermediate resistance to glycopeptides. Methods: Graft infections were established in
the subcutaneous tissue of adult male Wistar rats by implantation
of Dacron prostheses, followed by topical inoculation with S.
epidermidis. The study comprised: one group without inoculation;
one inoculated group without prophylaxis; six inoculated groups
that received intraperitoneal linezolid (8 mg/kg), levofloxacin
(7 mg/kg) or vancomycin (7 mg/kg) alone or in combination at the
dosages mentioned above. Each group included 20 animals. The grafts
were removed after 7 days and evaluated by quantitative culture. Results: Quantitative graft cultures from animals
treated with a single drug showed a significant efficacy only for
linezolid. The efficacy of levofloxacin was similar to that of vancomycin.
Combination studies demonstrated that only the treatments that included
linezolid produced no evidence of staphylococcal infection. Conclusions: Linezolid as perioperative prophylaxis
can be useful for the prevention of graft infections caused by multiresistant
staphylococcal strains.
Keywords: antibiotic prophylaxis, oxazolidinones, vascular
surgery, GISE
Prophylactic efficacy of linezolid alone or combined
with levofloxacin and vancomycin in a rat subcutaneous pouch model
of graft infection caused by Staphylococcus epidermidis with
intermediate resistance to glycopeptides
2 Department of General Surgery, I.N.R.C.A.
I.R.C.C.S., University of Ancona, Ancona
3 Biotechnology Centre, Research Department,
I.N.R.C.A. I.R.R.C.S., Ancona, Italy
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