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JAC Advance Access published online on September 1, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg389
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

Isolation of streptogramin-resistant Enterococcus faecium from human and non-human sources in a rural community

Sue Solway 1 *, Lindsey Vincent 1 , Natasha Tian 2 , Neil Woodford 2 , and Richard Bendall 1

1 Truro Public Health Laboratory, Penventinnie Lane, Treliske, Truro, Cornwall TR1 3LQ
2 Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, UK

* Corresponding author. E-mail: sue_solway{at}hotmail.com.

Received 9 April 2003 ; revised 22 June 2003 ; accepted 25 June 2003

Abstract

Objectives: To detect quinupristin-dalfopristin and virginiamycin M1 resistance in Enterococcus faecium from human, food and environmental sources.

Materials and methods: Enterococcal isolates derived from human faeces and urine, meat and seawater were screened for resistance to quinupristin-dalfopristin and virginiamycin M1 by an agar dilution method. Identification of all E. faecium strains and the presence of streptogramin acetyltransferase genes were confirmed using a PCR method.

Results: No high-level quinupristin-dalfopristin-resistant strains were isolated. Two isolates from faeces and five from seawater were confirmed to be high-level virginiamycin M1-resistant E. faecium (MIC 32 mg/L); none of these carried the vat(D) or vat(E) acetyltransferase genes that mediate high-level resistance to streptogramin A compounds.

Conclusion: High-level quinupristin-dalfopristin-resistant strains of E. faecium are uncommon in Cornwall. However streptogramin A-resistant strains were detected from human and animal sources.

Keywords: antibiotic resistance, animal husbandry, epidemiology
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