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JAC Advance Access published online on August 13, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg371
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae

Naoyuki Miyashita 1 *, Hiroshi Fukano 1 , Koichiro Yoshida 1 , Yoshihito Niki 1 , and Toshiharu Matsushima 1

1 Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan

* Corresponding author. E-mail: nao{at}med.kawasaki-m.ac.jp.

Received 14 February 2003 ; revised 13 June 2003 ; accepted 17 June 2003

Abstract

Objectives: To investigate the in vitro activity of cethromycin, a new ketolide, against Chlamydia pneumoniae.

Methods: The in vitro activity of cethromycin against 20 isolates of C. pneumoniae was compared with the activities of telithromycin, erythromycin A, azithromycin and clarithromycin against those isolates.

Results: The MIC at which 90% of the isolates were inhibited and the minimal chlamydiacidal concentration at which 90% of the isolates were killed by cethromycin were both 0.016 mg/L (range 0.016-0.031 mg/L). Cethromycin was the most active antibiotic tested in this study.

Conclusions: Our results appear to indicate that cethromycin is an effective antibiotic that should play some role in the treatment of respiratory tract infections caused by C. pneumoniae.

Keywords: macrolides, telithromycin, community-acquired pneumonia
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