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JAC Advance Access published online on July 15, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg363
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

Susceptibility of Yersinia pestis to novel and conventional antimicrobial agents

John Frean 1 , Keith P. Klugman 2 *, Lorraine Arntzen 1 , and Stanley Bukofzer 3

1 National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg
2 MRC/University of the Witwatersrand/NHLS Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa; Department of International Health, Emory University, Atlanta, GA, USA
3 Abbott Laboratories, Abbott Park, Chicago, IL, USA

* Corresponding author. E-mail: kklugma{at}sph.emory.edu.

Received 3 April 2003 ; revised 4 June 2003 ; accepted 10 June 2003

Abstract

Objectives: To determine the susceptibility of southern African strains of Yersinia pestis to novel as well as conventional antimicrobial agents.

Materials and methods: The MICs of 28 strains of Yersinia pestis from a southern African plague focus were determined by agar dilution.

Results: The most active agents were cefditoren and the fluoroquinolones, both conventional and novel. The in vitro activity of macrolides was poor against this member of the Enterobacteriaceae.

Conclusion: Further investigation of the novel quinolones olamufloxacin (HSR 903) and ABT 492 in animal models of plague would seem to be justified.

Keywords: plague, antibiotics, fluoroquinolones, macrolides, ketolides
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