JAC Advance Access published online on July 1, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg316
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Anaerobe Reference Laboratory, National Public Health Service
Wales, Microbiology Cardiff, University Hospital of Wales, Cardiff
CF14 4XW, UK
* Corresponding author. E-mail: Brazier{at}Cardiff.ac.uk.
Received 19 February 2003
; revised 2 May 2003
; accepted 3 May 2003
Objective: A sentinel study was carried
out to determine the antimicrobial susceptibilities of Gram-positive anaerobic
cocci (GPAC) freshly isolated from clinical material in diagnostic
laboratories in England and Wales. Methods: A total of 113 GPAC isolates consisting
predominantly of current or former members of the genus Peptostreptococcus was
obtained from 17 sentinel laboratories in England and one in Wales. Minimum inhibitory concentrations (MICs) of 10
antimicrobial agents were determined by the Etest method. The agents
tested were: penicillin, tetracycline, erythromycin, cefoxitin,
clindamycin, chloramphenicol, imipenem, co-amoxiclav, piperacillin/tazobactam
and metronidazole. MIC50 and MIC90 values
for each drug-species combination were calculated whenever suitable
numbers of each species were obtained. Results: Excellent spectra of activity (0% resistance)
against GPAC were seen for metronidazole, piperacillin/tazobactam,
cefoxitin, imipenem and chloramphenicol. Low degrees of resistance
to co-amoxiclav (3.5%), clindamycin (7.1%), penicillin
(7.1%) and significant degrees of resistance to tetracycline
(41.6%) and erythromycin (27.4%) were detected.
Some examples of putative macrolide-lincosamide linked resistance were
noted in seven (6.2%) isolates of GPAC. Conclusion: This study is one of the largest
susceptibility studies specifically on GPAC carried out to date and
the resulting data may be of value to those involved in the empirical
treatment of infections involving Gram-positive anaerobic cocci.
Keywords: Peptostreptococcus spp., Etests,
anaerobes, MICs
Antibiotic susceptibilities of Gram-positive anaerobic
cocci: results of a sentinel study in England and Wales
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