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JAC Advance Access published online on June 12, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg299
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Original article

Evolution of an integron carrying blaVIM-2 in Eastern Europe: report from the SENTRY Antimicrobial Surveillance Program

Timothy R. Walsh 1 *, Mark A. Toleman 1 , Waleria Hryniewicz 2 , Peter M. Bennett 1 , and Ronald N. Jones 3

1 Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, UK
2 Central Research Laboratory, Warsaw, Poland
3 The JONES Group/JMI Laboratories, North Liberty, IA; Tufts University School of Medicine, Boston, MA, USA

* Corresponding author. E-mail: t.r.walsh{at}bristol.ac.uk.

Received 22 November 2002 ; revised 14 April 2003 ; accepted 16 April 2003

Abstract

As part of the SENTRY Antimicrobial Surveillance Program, an imipenem-resistant Pseudomonas aeruginosa strain (81-11963A) was isolated from the blood culture of a female neonate institutionalized at the local children's hospital in Warsaw, Poland. Cloning of an imipenem resistance determinant revealed it to be a VIM-2 metallo-{beta}-lactamase, but sequence analysis of DNA adjacent to blaVIM-2 revealed it to have a unique gene context. Downstream of the blaVIM-2 gene resides an aacA4 gene encoding the AAC(6')-Ib aminoglycoside acetyltransferase. The integron containing blaVIM-2 shows high similarity to that reported from In58 in France but was novel in that it possessed a gene cassette with a 59 truncated base element only 19 base pairs (bp) long, consisting of a conserved core site and an inverse core site separated by only 5 bp. This appears to be the first report of a metallo-{beta}-lactamase gene arising from a pathogenic strain in Eastern Europe.

Keywords: metallo-{beta}-lactamases, Poland, Pseudomonas aeruginosa
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